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Those fatty acids activate receptors on intestinal L-cells that trigger the release of GLP-1 and PYY, two hormones that increase feelings of fullness

Safety Considerations As with any compounded sterile injectable, prescribers should screen patients before administration: G6PD deficiency: Patients with known or suspected G6PD deficiency should be evaluated carefully, as IV glutathione and related sulfhydryl compounds have been associated with hemolysis in this population

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Interestingly, in echidna GLP-1 there is less conservation of the receptor binding residues with additional changes at the N-terminal receptor binding Phe 12 (conservatively substituted to Tyr) and Asp 15 (changed to Glu) residues