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The extracellular part comprises two domains: a catalytic domain (residues 508766), which includes a catalytic triad of Ser630, Asp708, and His740, and adopts an /hydrolase fold, as well as an eightbladed propeller structure (residues 56497) that also contributes to the inhibitor binding site (Figure 2a) [40, 42]

They work by regulating appetite, slowing digestion, and improving blood sugar controland are FDA-approved for weight loss or diabetes management

Semaglutide's once-weekly injection schedule became the standard in clinical practice after the SUSTAIN trials demonstrated consistent weight loss and metabolic improvements on this regimen