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(1S,3R)-RSL3 is another potential ferroptosis agonist that directly inhibits GPX4, and TBHP was used to simulate oxidative stress conditions, which ultimately resulted in considerable lipid peroxidation [6, 28]

Co-exposure of Bi(2)O(3) nanoparticles and bezo[a]pyrene-enhanced in vitro cytotoxicity of mouse spermatogonia cells

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In order to treat and prevent ROS in gastric cancer, it may be crucial to focus on the enhancement of ROS by neutralizing antioxidants to induce cancer cell death, and the inhibition of ROS activity or increase of antioxidant capacity to regulate pro-tumorigenic signaling pathways