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Researchers measure outcomes such as cell proliferation rate, migration assay results, collagen secretion (via ELISA or hydroxyproline assay), and gene expression changes via quantitative PCR or transcriptomics
The combination remains speculative but represents logical stacking based on mechanism understanding
However, it should be noted that there is currently little scientific evidence to support any of these approaches.(1, 2) One recent study in mice found that feeding of a high FODMAP diet for 2 weeks resulted in an increase in gut permeability when compared to mice fed a standard diet.(7) The same study also showed that a 4-week low FODMAP diet could normalise intestinal permeability in rodents subject to high levels of stress (psychological stress is known to increase gut permeability).(7) Whether or not these results actually translate to the human gut is not known, but this is an interesting finding that might shed more light on how a low FODMAP diet provides symptom relief in IBS
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