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The conventional antidote for acetaminophen toxicity, N-acetyl cysteine (NAC), begins to lose efficacy if administered more than 8-10 hours following overdose (Smilkstein 1988
Monolayer chondrocytes were infected with control adenovirus containing green fluorescence protein (Ad-GFP) or Cre recombinase virus M1 (Ad-Cre) (Vector Laboratories, Burlingame, CA, USA) at an MOI of 100 for most experiments
During autooxidation of glucose, enzymatic pathways, such as the NOX pathway, become the main sources of ROS 38,39
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