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Taken together, available data support a central role of mitochondriacytoskeleton crosstalk in maintaining mitochondrial distribution, morphology, and quality control in PACs and in determining whether cells adapt to injury or progress toward death in AP ( 3.3 Mitochondria and the plasma membrane At the cell periphery, these intracellular mechanisms converge on the plasma membrane, where calcium entry both drives physiological secretion and, when excessive, perpetuates mitochondrial injury

Despite the proven efficacy of drugs that ameliorate the adverse effects of SSRIs, the small sample sizes of studies and the lack of deeper mechanistic elaboration have slowed the clinical application of these research findings