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Surgery is generally reserved for cases with progressive neurological deficits, cauda equina syndrome (a surgical emergency), or persistent symptoms despite 6 to 12 months of conservative treatment

The effect of glutathione is limited and thereby it has to be maintained

For the spray, one dose twice daily with 30-60 seconds of sublingual holding is recommended

Furthermore, the Polish Diabetes Association has addressed the issue of the optimal timing for the cessation of SGLT2 inhibitors and GLP-1RAs, recommending withholding SGLT2 inhibitors for three days prior to surgery and omitting one dose of weekly administered GLP-1RA [41]